Our laboratory is affiliated to the University of Florida College of Medicine. The research areas in the lab include Biochemistry, Biophysics, and Molecular and Cell Biology. Many of UF undergraduate and graduate students and students from Eastside High School and P.K. Yonge Developmental Research School come to our lab to do research in these areas.

The lab is run by Michael Bubb and Elena Yarmola

The laboratory studies the regulation of actin polymerization in cell motility. We investigate the cell biology, biochemistry and biophysics of actin-binding proteins specifically as they pertain to such topics as apoptosis, angiogenesis, immunology and cancer biology. We also study pharmacologic agents that affect actin polymerization. We use a variety of biophysical techniques to answer specific questions regarding mechanisms controlling cell motility, including time-dependent fluorescence spectroscopy and analytical ultracentrifugation.

We study molecular mechanisms in actin regulation not only experimentally but also theoretically. Theoretical study includes molecular dynamics simulations and mathematical and computer modeling. Please go to What is ABAKUS? to review and use our recent model for the actin regulating protein profilin.

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